MBD4 frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells

BACKGROUNDS: Trifluridine is an active antitumor component of TAS-102 that resembles 5-fluorouracil. Although patients with advanced colorectal cancer (CRC) exhibiting a mismatch repair (MMR) deficiency reportedly do not benefit from 5-fluorouracil-based chemotherapy and we previously reported that...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Suzuki, Satoshi, Iwaizumi, Moriya, Yamada, Hidetaka, Sugiyama, Tomohiro, Hamaya, Yasushi, Furuta, Takahisa, Kanaoka, Shigeru, Sugimura, Haruhiko, Miyajima, Hiroaki, Osawa, Satoshi, Carethers, John M., Sugimoto, Ken
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837757/
https://ncbi.nlm.nih.gov/pubmed/29545913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22484
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