Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity

Human DNA mismatch repair (MMR) recognizes and binds 5-fluorouracil (5FU) incorporated into DNA and triggers a MMR-dependent cell death. Absence of MMR in a patient's colorectal tumor abrogates 5FU's beneficial effects on survival. Changes in the tumor microenvironment like low extracellul...

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Detaylı Bibliyografya
Asıl Yazarlar: Iwaizumi, Moriya, Tseng-Rogenski, Stephanie, Carethers, John M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770844/
https://ncbi.nlm.nih.gov/pubmed/23643670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2013.04.006
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