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Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity
Human DNA mismatch repair (MMR) recognizes and binds 5-fluorouracil (5FU) incorporated into DNA and triggers a MMR-dependent cell death. Absence of MMR in a patient's colorectal tumor abrogates 5FU's beneficial effects on survival. Changes in the tumor microenvironment like low extracellul...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770844/ https://ncbi.nlm.nih.gov/pubmed/23643670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2013.04.006 |
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