Computational Design of Selective Peptides to Discriminate Between Similar PDZ Domains in an Oncogenic Pathway

Reagents that target protein-protein interactions to rewire signaling are of great relevance in biological research. Computational protein design may offer a means of creating such reagents on demand, but methods for encoding targeting selectivity are sorely needed. This is especially challenging wh...

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Vydáno v:J Mol Biol
Hlavní autoři: Zheng, Fan, Jewell, Heather, Fitzpatrick, Jeremy, Zhang, Jian, Mierke, Dale F., Grigoryan, Gevorg
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970318/
https://ncbi.nlm.nih.gov/pubmed/25451599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.10.014
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