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Specificity of antisense oligonucleotides in vivo.

Antisense oligonucleotides are widely used as inhibitors of gene expression in cultured cells and have been proposed as potential therapeutic agents, but it is not known to what extent they are specific for their intended target RNAs. Statistical considerations indicate that if oligonucleotides can...

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Main Authors: Woolf, T M, Melton, D A, Jennings, C G
格式: Artigo
語言:Inglês
出版: 1992
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC49698/
https://ncbi.nlm.nih.gov/pubmed/1380154
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