Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

Stromal cells and osteoblasts play major roles in forming and modulating the bone marrow (BM) hematopoietic microenvironment. We have reported that FGF2 compromises stromal cell support of normal hematopoiesis. Here, we examined the effects of FGF2 on the leukemia microenvironment. In vitro, FGF2 si...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Sugimoto, Keiki, Miyata, Yasuhiko, Nakayama, Takayuki, Saito, Shigeki, Suzuki, Ritsuro, Hayakawa, Fumihiko, Nishiwaki, Satoshi, Mizuno, Hiroki, Takeshita, Kyosuke, Kato, Hidefumi, Ueda, Ryuzo, Takami, Akiyoshi, Naoe, Tomoki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969776/
https://ncbi.nlm.nih.gov/pubmed/27481339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30779
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