Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

Stromal cells and osteoblasts play major roles in forming and modulating the bone marrow (BM) hematopoietic microenvironment. We have reported that FGF2 compromises stromal cell support of normal hematopoiesis. Here, we examined the effects of FGF2 on the leukemia microenvironment. In vitro, FGF2 si...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Sugimoto, Keiki, Miyata, Yasuhiko, Nakayama, Takayuki, Saito, Shigeki, Suzuki, Ritsuro, Hayakawa, Fumihiko, Nishiwaki, Satoshi, Mizuno, Hiroki, Takeshita, Kyosuke, Kato, Hidefumi, Ueda, Ryuzo, Takami, Akiyoshi, Naoe, Tomoki
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969776/
https://ncbi.nlm.nih.gov/pubmed/27481339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30779
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