Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

Stromal cells and osteoblasts play major roles in forming and modulating the bone marrow (BM) hematopoietic microenvironment. We have reported that FGF2 compromises stromal cell support of normal hematopoiesis. Here, we examined the effects of FGF2 on the leukemia microenvironment. In vitro, FGF2 si...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sugimoto, Keiki, Miyata, Yasuhiko, Nakayama, Takayuki, Saito, Shigeki, Suzuki, Ritsuro, Hayakawa, Fumihiko, Nishiwaki, Satoshi, Mizuno, Hiroki, Takeshita, Kyosuke, Kato, Hidefumi, Ueda, Ryuzo, Takami, Akiyoshi, Naoe, Tomoki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969776/
https://ncbi.nlm.nih.gov/pubmed/27481339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30779
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