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Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing

Disease-specific antibodies can serve as highly effective biomarkers but have been identified for only a relatively small number of autoimmune diseases. A method was developed to identify disease-specific binding motifs through integration of bacterial display peptide library screening, next-generat...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Pantazes, Robert J., Reifert, Jack, Bozekowski, Joel, Ibsen, Kelly N., Murray, Joseph A., Daugherty, Patrick S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969583/
https://ncbi.nlm.nih.gov/pubmed/27481573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30312
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