Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

Mitochondrial dysfunction and accumulation of damaged mitochondria are considered major contributors to aging. However, the molecular mechanisms responsible for these mitochondrial alterations remain unknown. Here, we demonstrate that mitofusin 2 (Mfn2) plays a key role in the control of muscle mito...

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Vydáno v:EMBO J
Hlavní autoři: Sebastián, David, Sorianello, Eleonora, Segalés, Jessica, Irazoki, Andrea, Ruiz‐Bonilla, Vanessa, Sala, David, Planet, Evarist, Berenguer‐Llergo, Antoni, Muñoz, Juan Pablo, Sánchez‐Feutrie, Manuela, Plana, Natàlia, Hernández‐Álvarez, María Isabel, Serrano, Antonio L, Palacín, Manuel, Zorzano, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969577/
https://ncbi.nlm.nih.gov/pubmed/27334614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593084
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