Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

Mitochondrial dysfunction and accumulation of damaged mitochondria are considered major contributors to aging. However, the molecular mechanisms responsible for these mitochondrial alterations remain unknown. Here, we demonstrate that mitofusin 2 (Mfn2) plays a key role in the control of muscle mito...

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Detaylı Bibliyografya
Yayımlandı:EMBO J
Asıl Yazarlar: Sebastián, David, Sorianello, Eleonora, Segalés, Jessica, Irazoki, Andrea, Ruiz‐Bonilla, Vanessa, Sala, David, Planet, Evarist, Berenguer‐Llergo, Antoni, Muñoz, Juan Pablo, Sánchez‐Feutrie, Manuela, Plana, Natàlia, Hernández‐Álvarez, María Isabel, Serrano, Antonio L, Palacín, Manuel, Zorzano, Antonio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969577/
https://ncbi.nlm.nih.gov/pubmed/27334614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593084
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