Ursolic acid attenuates temozolomide resistance in glioblastoma cells by downregulating O(6)-methylguanine-DNA methyltransferase (MGMT) expression

The DNA-alkylating agent temozolomide (TMZ) is an effective chemotherapeutic agent against malignant glioma, including glioblastoma multiforme (GBM). However, the clinical efficacy of TMZ is limited in many patients because of O(6)-methylguanine-DNA methyltransferase (MGMT)-driven resistance. Thus,...

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Detalles Bibliográficos
Publicado en:Am J Transl Res
Main Authors: Zhu, Zhongling, Du, Shuangshuang, Ding, Fengxia, Guo, Shanshan, Ying, Guoguang, Yan, Zhao
Formato: Artigo
Idioma:Inglês
Publicado: e-Century Publishing Corporation 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969467/
https://ncbi.nlm.nih.gov/pubmed/27508051
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