Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation

Mammalian target of rapamycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) phosphorylation promotes cap-dependent translation and tumorigenesis. During mitosis, cyclin-dependent kinase 1 (CDK1) substitutes for mTOR and fully phosphorylates 4E-BP1 at canonica...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Velásquez, Celestino, Cheng, Erdong, Shuda, Masahiro, Lee-Oesterreich, Paula J., Pogge von Strandmann, Lisa, Gritsenko, Marina A., Jacobs, Jon M., Moore, Patrick S., Chang, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968757/
https://ncbi.nlm.nih.gov/pubmed/27402756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607768113
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados