Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation

Mammalian target of rapamycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) phosphorylation promotes cap-dependent translation and tumorigenesis. During mitosis, cyclin-dependent kinase 1 (CDK1) substitutes for mTOR and fully phosphorylates 4E-BP1 at canonica...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Velásquez, Celestino, Cheng, Erdong, Shuda, Masahiro, Lee-Oesterreich, Paula J., Pogge von Strandmann, Lisa, Gritsenko, Marina A., Jacobs, Jon M., Moore, Patrick S., Chang, Yuan
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2016
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968757/
https://ncbi.nlm.nih.gov/pubmed/27402756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607768113
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