Danazol Treatment for Telomere Diseases

BACKGROUND: Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, and pulmonary fibrosis, and they increase susceptibility to cancer. Historically, androgens have been useful as treatment for marrow failure syndromes. In tissue culture and animal models, sex...

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Gepubliceerd in:N Engl J Med
Hoofdauteurs: Townsley, Danielle M., Dumitriu, Bogdan, Liu, Delong, Biancotto, Angélique, Weinstein, Barbara, Chen, Christina, Hardy, Nathan, Mihalek, Andrew D., Lingala, Shilpa, Kim, Yun Ju, Yao, Jianhua, Jones, Elizabeth, Gochuico, Bernadette R., Heller, Theo, Wu, Colin O., Calado, Rodrigo T., Scheinberg, Phillip, Young, Neal S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968696/
https://ncbi.nlm.nih.gov/pubmed/27192671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1515319
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