Danazol Treatment for Telomere Diseases

BACKGROUND: Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, and pulmonary fibrosis, and they increase susceptibility to cancer. Historically, androgens have been useful as treatment for marrow failure syndromes. In tissue culture and animal models, sex...

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Detalhes bibliográficos
Publicado no:N Engl J Med
Main Authors: Townsley, Danielle M., Dumitriu, Bogdan, Liu, Delong, Biancotto, Angélique, Weinstein, Barbara, Chen, Christina, Hardy, Nathan, Mihalek, Andrew D., Lingala, Shilpa, Kim, Yun Ju, Yao, Jianhua, Jones, Elizabeth, Gochuico, Bernadette R., Heller, Theo, Wu, Colin O., Calado, Rodrigo T., Scheinberg, Phillip, Young, Neal S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968696/
https://ncbi.nlm.nih.gov/pubmed/27192671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1515319
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