Local fitness landscape of the green fluorescent protein

Fitness landscapes1,2, depictions of how genotypes manifest at the phenotypic level, form the basis for our understanding of many areas of biology2–7 yet their properties remain elusive. Studies addressing this issue often consider specific genes and their function as proxy for fitness2,4, experimen...

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Udgivet i:Nature
Main Authors: Sarkisyan, Karen S., Bolotin, Dmitry A., Meer, Margarita V., Usmanova, Dinara R., Mishin, Alexander S., Sharonov, George V., Ivankov, Dmitry N., Bozhanova, Nina G., Baranov, Mikhail S., Soylemez, Onuralp, Bogatyreva, Natalya S., Vlasov, Peter K., Egorov, Evgeny S., Logacheva, Maria D., Kondrashov, Alexey S., Chudakov, Dmitry M., Putintseva, Ekaterina V., Mamedov, Ilgar Z., Tawfik, Dan S., Lukyanov, Konstantin A., Kondrashov, Fyodor A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968632/
https://ncbi.nlm.nih.gov/pubmed/27193686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17995
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