An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape

Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the evolutionarily-relevant segment of the fitness landscape of His3, a gene coding for an...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Pokusaeva, Victoria O., Usmanova, Dinara R., Putintseva, Ekaterina V., Espinar, Lorena, Sarkisyan, Karen S., Mishin, Alexander S., Bogatyreva, Natalya S., Ivankov, Dmitry N., Akopyan, Arseniy V., Avvakumov, Sergey Ya., Povolotskaya, Inna S., Filion, Guillaume J., Carey, Lucas B., Kondrashov, Fyodor A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476524/
https://ncbi.nlm.nih.gov/pubmed/30969963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008079
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