Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.
Twenty-seven cases of inflammatory breast cancer were screened for the presence of the p53 protein by immunocytochemical methods using a monoclonal antibody directed against the p53 protein. Three groups were detected: 8 cases (30%) had high levels of p53 in the nucleus of the cancer cells; 9 cases...
Guardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1992
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1353891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.15.7262 |
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