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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

Twenty-seven cases of inflammatory breast cancer were screened for the presence of the p53 protein by immunocytochemical methods using a monoclonal antibody directed against the p53 protein. Three groups were detected: 8 cases (30%) had high levels of p53 in the nucleus of the cancer cells; 9 cases...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Moll, U M, Riou, G, Levine, A J
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49686/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1353891/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.15.7262
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