GATA1 Binding Kinetics on Conformation-Specific Binding Sites Elicit Differential Transcriptional Regulation

GATA1 organizes erythroid and megakaryocytic differentiation by orchestrating the expression of multiple genes that show diversified expression profiles. Here, we demonstrate that GATA1 monovalently binds to a single GATA motif (Single-GATA) while a monomeric GATA1 and a homodimeric GATA1 bivalently...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Hasegawa, Atsushi, Kaneko, Hiroshi, Ishihara, Daishi, Nakamura, Masahiro, Watanabe, Akira, Yamamoto, Masayuki, Trainor, Cecelia D., Shimizu, Ritsuko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968217/
https://ncbi.nlm.nih.gov/pubmed/27215385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00017-16
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