GATA1 Binding Kinetics on Conformation-Specific Binding Sites Elicit Differential Transcriptional Regulation

GATA1 organizes erythroid and megakaryocytic differentiation by orchestrating the expression of multiple genes that show diversified expression profiles. Here, we demonstrate that GATA1 monovalently binds to a single GATA motif (Single-GATA) while a monomeric GATA1 and a homodimeric GATA1 bivalently...

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Bibliografske podrobnosti
izdano v:Mol Cell Biol
Main Authors: Hasegawa, Atsushi, Kaneko, Hiroshi, Ishihara, Daishi, Nakamura, Masahiro, Watanabe, Akira, Yamamoto, Masayuki, Trainor, Cecelia D., Shimizu, Ritsuko
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968217/
https://ncbi.nlm.nih.gov/pubmed/27215385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00017-16
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