SCF(Fbl12) Increases p21(Waf1/Cip1) Expression Level through Atypical Ubiquitin Chain Synthesis

The cyclin-dependent kinase (CDK) inhibitor p21 is an unstructured protein regulated by multiple turnover pathways. p21 abundance is tightly regulated, and its defect causes tumor development. However, the mechanisms that underlie the control of p21 level are not fully understood. Here, we report a...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Tsuruta, Fuminori, Takebe, Ai, Haratake, Kousuke, Kanemori, Yoshinori, Kim, Jaehyun, Endo, Tomoyuki, Kigoshi, Yu, Fukuda, Tomomi, Miyahara, Hatsumi, Ebina, Manato, Baba, Tadashi, Chiba, Tomoki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968210/
https://ncbi.nlm.nih.gov/pubmed/27215384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00174-16
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