Serum pharmacokinetics and cerebrospinal fluid concentration analysis of the new IgG4 monoclonal antibody GNbAC1 to treat multiple sclerosis: A Phase 1 study

GNbAC1 is a humanized IgG4 monoclonal antibody antagonist of Mulitple Sclerosis Retrovirus Envelope (MSRV-Env), a protein that could play a critical role in multiple sclerosis. This randomized placebo-controlled dose-escalation study evaluated the safety and pharmacokinetics of GNbAC1 in 21 healthy...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Curtin, François, Vidal, Virginie, Bernard, Corinne, Kromminga, Arno, Lang, Alois B., Porchet, Hervé
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968100/
https://ncbi.nlm.nih.gov/pubmed/27030142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1168956
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