Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statisti...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Schumacher, Fredrick R., Schmit, Stephanie L., Jiao, Shuo, Edlund, Christopher K., Wang, Hansong, Zhang, Ben, Hsu, Li, Huang, Shu-Chen, Fischer, Christopher P., Harju, John F., Idos, Gregory E., Lejbkowicz, Flavio, Manion, Frank J., McDonnell, Kevin, McNeil, Caroline E., Melas, Marilena, Rennert, Hedy S., Shi, Wei, Thomas, Duncan C., Van Den Berg, David J., Hutter, Carolyn M., Aragaki, Aaron K., Butterbach, Katja, Caan, Bette J., Carlson, Christopher S., Chanock, Stephen J., Curtis, Keith R., Fuchs, Charles S., Gala, Manish, Giovannucci, Edward L., Gogarten, Stephanie M., Hayes, Richard B., Henderson, Brian, Hunter, David J., Jackson, Rebecca D., Kolonel, Laurence N., Kooperberg, Charles, Küry, Sébastien, LaCroix, Andrea, Laurie, Cathy C., Laurie, Cecelia A., Lemire, Mathieu, Levine, David, Ma, Jing, Makar, Karen W., Qu, Conghui, Taverna, Darin, Ulrich, Cornelia M., Wu, Kana, Kono, Suminori, West, Dee W., Berndt, Sonja I., Bezieau, Stéphane, Brenner, Hermann, Campbell, Peter T., Chan, Andrew T., Chang-Claude, Jenny, Coetzee, Gerhard A., Conti, David V., Duggan, David, Figueiredo, Jane C., Fortini, Barbara K., Gallinger, Steven J., Gauderman, W. James, Giles, Graham, Green, Roger, Haile, Robert, Harrison, Tabitha A., Hoffmeister, Michael, Hopper, John L., Hudson, Thomas J., Jacobs, Eric, Iwasaki, Motoki, Jee, Sun Ha, Jenkins, Mark, Jia, Wei-Hua, Joshi, Amit, Li, Li, Lindor, Noralene M., Matsuo, Keitaro, Moreno, Victor, Mukherjee, Bhramar, Newcomb, Polly A., Potter, John D., Raskin, Leon, Rennert, Gad, Rosse, Stephanie, Severi, Gianluca, Schoen, Robert E., Seminara, Daniela, Shu, Xiao-Ou, Slattery, Martha L., Tsugane, Shoichiro, White, Emily, Xiang, Yong-Bing, Zanke, Brent W., Zheng, Wei, Le Marchand, Loic, Casey, Graham, Gruber, Stephen B., Peters, Ulrike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967357/
https://ncbi.nlm.nih.gov/pubmed/26151821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8138
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