Copy number deletion of RAD50 as predictive marker of BRCAness and PARP inhibitor response in BRCA wild type ovarian cancer

OBJECTIVE: To identify novel prognostic and therapeutic markers for PARP inhibitors in BRCA wild type ovarian cancer (OvCa). METHODS: BRCAness status was defined by analyzing whole-exome deep sequencing data from 220 BRCAwt OvCa cases in TCGA. Thirty-three DNA-repair genes were screened in an integr...

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Publicado en:Gynecol Oncol
Autores principales: Zhang, Min, Liu, Guoyan, Xue, Fengxia, Edwards, Robert, Sood, Anil K., Zhang, Wei, Yang, Da
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967351/
https://ncbi.nlm.nih.gov/pubmed/27016230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2016.01.004
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