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ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells

The development of chronic hypoxia (CH)-induced pulmonary hypertension is associated with increased pulmonary arterial smooth muscle cell (PASMC) Ca(2+) influx through acid-sensing ion channel-1 (ASIC1) and activation of the Ca(2+)/calcineurin-dependent transcription factor known as nuclear factor o...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Gonzalez Bosc, Laura V., Plomaritas, Danielle R., Herbert, Lindsay M., Giermakowska, Wieslawa, Browning, Carly, Jernigan, Nikki L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967194/
https://ncbi.nlm.nih.gov/pubmed/27190058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00040.2016
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