Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection

Chromosomal instability is a well-defined hallmark of tumor aggressiveness and metastatic progression in colorectal cancer. The magnitude of genetic heterogeneity among distinct liver metastases from the same patient at the copy number level, as well as its relationship with chemotherapy exposure an...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Sveen, Anita, Løes, Inger Marie, Alagaratnam, Sharmini, Nilsen, Gro, Høland, Maren, Lingjærde, Ole Christian, Sorbye, Halfdan, Berg, Kaja Christine Graue, Horn, Arild, Angelsen, Jon-Helge, Knappskog, Stian, Lønning, Per Eystein, Lothe, Ragnhild A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966938/
https://ncbi.nlm.nih.gov/pubmed/27472274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006225
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