Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection

Chromosomal instability is a well-defined hallmark of tumor aggressiveness and metastatic progression in colorectal cancer. The magnitude of genetic heterogeneity among distinct liver metastases from the same patient at the copy number level, as well as its relationship with chemotherapy exposure an...

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Dades bibliogràfiques
Publicat a:PLoS Genet
Autors principals: Sveen, Anita, Løes, Inger Marie, Alagaratnam, Sharmini, Nilsen, Gro, Høland, Maren, Lingjærde, Ole Christian, Sorbye, Halfdan, Berg, Kaja Christine Graue, Horn, Arild, Angelsen, Jon-Helge, Knappskog, Stian, Lønning, Per Eystein, Lothe, Ragnhild A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966938/
https://ncbi.nlm.nih.gov/pubmed/27472274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006225
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