Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes

CD56 (NCAM, neural cell adhesion molecule) is over-expressed in many tumor types, including neuroblastoma, multiple myeloma, small cell lung cancer, ovarian cancer, acute myeloid leukemia, NK-T lymphoma, neuroendocrine cancer and pancreatic cancer. Using phage display, we identified 2 high-affinity...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Feng, Yang, Wang, Yanping, Zhu, Zhongyu, Li, Wei, Sussman, Robyn T., Randall, Michael, Bosse, Kristopher R., Maris, John M., Dimitrov, Dimiter S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966860/
https://ncbi.nlm.nih.gov/pubmed/26910291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1155014
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