A New Bispecific Antibody Targeting Non-overlapping Epitopes on IGF2: Design, in vitro Characterization and Pharmacokinetics in Macaques

The insulin-like growth factor 2 (IGF2) is an important target for cancer therapy. We have previously proposed an approach for fast and irreversible removal of IGF2 from the circulation by using monoclonal antibodies (mAbs) that bind to two or more non-overlapping epitopes on the same molecule. We p...

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Bibliographic Details
Published in:Exp Mol Pathol
Main Authors: Feng, Yang, Zhao, Qi, Chen, Weizao, Wang, Yanping, Crowder, Karalyne, Dimitrov, Dimiter S.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262567/
https://ncbi.nlm.nih.gov/pubmed/25220345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2014.09.007
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