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A New Bispecific Antibody Targeting Non-overlapping Epitopes on IGF2: Design, in vitro Characterization and Pharmacokinetics in Macaques
The insulin-like growth factor 2 (IGF2) is an important target for cancer therapy. We have previously proposed an approach for fast and irreversible removal of IGF2 from the circulation by using monoclonal antibodies (mAbs) that bind to two or more non-overlapping epitopes on the same molecule. We p...
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| Publicado en: | Exp Mol Pathol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4262567/ https://ncbi.nlm.nih.gov/pubmed/25220345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2014.09.007 |
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