Humanized mouse G6 anti-idiotypic monoclonal antibody has therapeutic potential against IGHV1-69 germline gene-based B-CLL

In 10–20% of the cases of chronic lymphocytic leukemia of B-cell phenotype (B-CLL), the IGHV1-69 germline is utilized as VH gene of the B cell receptor (BCR). Mouse G6 (MuG6) is an anti-idiotypic monoclonal antibody discovered in a screen against rheumatoid factors (RFs) that binds with high affinit...

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Publicado en:MAbs
Main Authors: Chang, De-Kuan, Kurella, Vinodh B., Biswas, Subhabrata, Avnir, Yuval, Sui, Jianhua, Wang, Xueqian, Sun, Jiusong, Wang, Yanyan, Panditrao, Madhura, Peterson, Eric, Tallarico, Aimee, Fernandes, Stacey, Goodall, Margaret, Zhu, Quan, Brown, Jennifer R., Jefferis, Roy, Marasco, Wayne A
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966851/
https://ncbi.nlm.nih.gov/pubmed/26963739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1159365
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