Humanized mouse G6 anti-idiotypic monoclonal antibody has therapeutic potential against IGHV1-69 germline gene-based B-CLL

In 10–20% of the cases of chronic lymphocytic leukemia of B-cell phenotype (B-CLL), the IGHV1-69 germline is utilized as VH gene of the B cell receptor (BCR). Mouse G6 (MuG6) is an anti-idiotypic monoclonal antibody discovered in a screen against rheumatoid factors (RFs) that binds with high affinit...

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Publicado no:MAbs
Main Authors: Chang, De-Kuan, Kurella, Vinodh B., Biswas, Subhabrata, Avnir, Yuval, Sui, Jianhua, Wang, Xueqian, Sun, Jiusong, Wang, Yanyan, Panditrao, Madhura, Peterson, Eric, Tallarico, Aimee, Fernandes, Stacey, Goodall, Margaret, Zhu, Quan, Brown, Jennifer R., Jefferis, Roy, Marasco, Wayne A
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966851/
https://ncbi.nlm.nih.gov/pubmed/26963739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1159365
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