Humanized mouse G6 anti-idiotypic monoclonal antibody has therapeutic potential against IGHV1-69 germline gene-based B-CLL

In 10–20% of the cases of chronic lymphocytic leukemia of B-cell phenotype (B-CLL), the IGHV1-69 germline is utilized as VH gene of the B cell receptor (BCR). Mouse G6 (MuG6) is an anti-idiotypic monoclonal antibody discovered in a screen against rheumatoid factors (RFs) that binds with high affinit...

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I publikationen:MAbs
Huvudupphovsmän: Chang, De-Kuan, Kurella, Vinodh B., Biswas, Subhabrata, Avnir, Yuval, Sui, Jianhua, Wang, Xueqian, Sun, Jiusong, Wang, Yanyan, Panditrao, Madhura, Peterson, Eric, Tallarico, Aimee, Fernandes, Stacey, Goodall, Margaret, Zhu, Quan, Brown, Jennifer R., Jefferis, Roy, Marasco, Wayne A
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2016
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966851/
https://ncbi.nlm.nih.gov/pubmed/26963739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1159365
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