IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity

IGHV polymorphism provides a rich source of humoral immune system diversity. One important example is the IGHV1-69 germline gene where the biased use of alleles that encode the critical CDR-H2 Phe54 (F-alleles) to make broadly neutralizing antibodies (HV1-69-sBnAb) to the influenza A hemagglutinin s...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Avnir, Yuval, Watson, Corey T., Glanville, Jacob, Peterson, Eric C., Tallarico, Aimee S., Bennett, Andrew S., Qin, Kun, Fu, Ying, Huang, Chiung-Yu, Beigel, John H., Breden, Felix, Zhu, Quan, Marasco, Wayne A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754645/
https://ncbi.nlm.nih.gov/pubmed/26880249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20842
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires