XGFR*, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer

The epidermal growth factor receptor (EGFR) and the insulin-like growth factor-1 receptor (IGF-1R) play critical roles in tumor growth, providing a strong rationale for the combined inhibition of IGF-1R and EGFR signaling in cancer therapy. We describe the design, affinity maturation, in vitro and i...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Schanzer, Juergen M., Wartha, Katharina, Moessner, Ekkehard, Hosse, Ralf J., Moser, Samuel, Croasdale, Rebecca, Trochanowska, Halina, Shao, Cuiying, Wang, Peng, Shi, Lei, Weinzierl, Tina, Rieder, Natascha, Bacac, Marina, Ries, Carola H., Kettenberger, Hubert, Schlothauer, Tilman, Friess, Thomas, Umana, Pablo, Klein, Christian
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966845/
https://ncbi.nlm.nih.gov/pubmed/26984378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1160989
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