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Effects of molecularly targeted therapies on murine thymus: highly selective mTOR inhibitors induce reversible thymic involution

BACKGROUND: Blocking mTOR (molecular target of rapamycin) by sirolimus has been shown to suppress cellular respiration. The bearing of this impaired cellular bioenergetics on the mode-of-action of mTOR inhibitors has yet to be illustrated. METHODS: This study investigated in vitro effects of several...

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Vydáno v:Exp Hematol Oncol
Hlavní autoři: Al-Hammadi, Suleiman, Almarzooqi, Saeeda, Albawardi, Alia, Souid, Abdul-Kader
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966723/
https://ncbi.nlm.nih.gov/pubmed/27478685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-016-0044-3
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