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Effects of molecularly targeted therapies on murine thymus: highly selective mTOR inhibitors induce reversible thymic involution

BACKGROUND: Blocking mTOR (molecular target of rapamycin) by sirolimus has been shown to suppress cellular respiration. The bearing of this impaired cellular bioenergetics on the mode-of-action of mTOR inhibitors has yet to be illustrated. METHODS: This study investigated in vitro effects of several...

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Dettagli Bibliografici
Pubblicato in:Exp Hematol Oncol
Autori principali: Al-Hammadi, Suleiman, Almarzooqi, Saeeda, Albawardi, Alia, Souid, Abdul-Kader
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966723/
https://ncbi.nlm.nih.gov/pubmed/27478685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-016-0044-3
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