Impact of Stepwise NH(2)-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

[Image: see text] One of the most promising classes of iron chelators are α-N-heterocyclic thiosemicarbazones with Triapine as the most prominent representative. In several clinical trials Triapine showed anticancer activity against hematological diseases, however, studies on solid tumors failed due...

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Publicado en:J Med Chem
Main Authors: Kowol, Christian R., Miklos, Walter, Pfaff, Sarah, Hager, Sonja, Kallus, Sebastian, Pelivan, Karla, Kubanik, Mario, Enyedy, Éva A., Berger, Walter, Heffeter, Petra, Keppler, Bernhard K.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2016
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966696/
https://ncbi.nlm.nih.gov/pubmed/27336684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00342
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