Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus

Urine concentration is regulated by vasopressin. Congenital nephrogenic diabetes insipidus (NDI) is caused by vasopressin type 2 receptor (V2R) mutations. We studied whether metformin could improve urine concentration in rodent models of congenital NDI by stimulating AMPK. To block the V2R in rats,...

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Udgivet i:JCI Insight
Main Authors: Efe, Orhan, Klein, Janet D., LaRocque, Lauren M., Ren, Huiwen, Sands, Jeff M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966685/
https://ncbi.nlm.nih.gov/pubmed/27478876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88409
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