An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus

Nephrogenic diabetes insipidus (NDI) patients produce large amounts of dilute urine. NDI can be congenital, resulting from mutations in the type-2 vasopressin receptor (V2R), or acquired, resulting from medications such as lithium. There are no effective treatment options for NDI. Activation of PKA...

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Publicado en:JCI Insight
Autores principales: Klein, Janet D., Khanna, Ish, Pillarisetti, Ram, Hagan, Rachael A., LaRocque, Lauren M., Rodriguez, Eva L., Sands, Jeff M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119225/
https://ncbi.nlm.nih.gov/pubmed/33724959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.146419
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