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Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus
Urine concentration is regulated by vasopressin. Congenital nephrogenic diabetes insipidus (NDI) is caused by vasopressin type 2 receptor (V2R) mutations. We studied whether metformin could improve urine concentration in rodent models of congenital NDI by stimulating AMPK. To block the V2R in rats,...
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| Publicat a: | JCI Insight |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966685/ https://ncbi.nlm.nih.gov/pubmed/27478876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88409 |
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