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HandaPhos. A general ligand enabling sustainable ppm levels of palladium-catalyzed cross-couplings in water at room temperature

A new monophosphine ligand, HandaPhos, has been identified that when complexed in a 1:1 ratio with Pd(OAc)(2), forms a catalyst that is generally useful, enabling Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this catalyst. Applications to heavily utilized Suzuki-Miyaura reactions involv...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Handa, Sachin, Andersson, Martin P., Gallou, Fabrice, Reilly, John, Lipshutz, Bruce H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966530/
https://ncbi.nlm.nih.gov/pubmed/26924396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201510570
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