Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines

Hypertrophic cardiomyopathy is a common cause of mortality in congenital heart disease (CHD). Many gene abnormalities are associated with cardiac hypertrophy, but their function in cardiac development is not well understood. Loss-of-function mutations in PTPN11, which encodes the protein tyrosine ph...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Lauriol, Jessica, Cabrera, Janel R., Roy, Ashbeel, Keith, Kimberly, Hough, Sara M., Damilano, Federico, Wang, Bonnie, Segarra, Gabriel C., Flessa, Meaghan E., Miller, Lauren E., Das, Saumya, Bronson, Roderick, Lee, Kyu-Ho, Kontaridis, Maria I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966304/
https://ncbi.nlm.nih.gov/pubmed/27348588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80396
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