Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm(20ΔRRM) Mice

Titin is a giant protein spanning from the Z-disk to the M-band of the cardiac sarcomere. In the I-band titin acts as a molecular spring, contributing to passive mechanical characteristics of the myocardium throughout a heartbeat. RNA Binding Motif Protein 20 (RBM20) is required for normal titin spl...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Pulcastro, Hannah C., Awinda, Peter O., Methawasin, Mei, Granzier, Henk, Dong, Wenji, Tanner, Bertrand C. W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966298/
https://ncbi.nlm.nih.gov/pubmed/27524973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00322
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