Increased titin compliance reduced length-dependent contractionand slowed cross-bridge kinetics in skinned myocardial strips from Rbm20ΔRRM mice

Titin is a giant protein spanning from the Z-disk to the M-band of the cardiac sarcomere. In the I-band titin acts as a molecular spring, contributing to passive mechanical characteristics of the myocardium throughout a heartbeat. RNA Binding Motif Protein 20 (RBM20) is required for normal titin spl...

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Main Authors: Hannah C. Pulcastro, Peter O. Awinda, Mei Methawasin, Henk Granzier, Wen-Ji Dong, Bertrand C.W. Tanner
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016-07-01
Colecção:Frontiers in Physiology
Assuntos:
length-dependent activation
cross-bridge kinetics
Frank-Starling relationship
Cardiac muscle contraction
titin compliance
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00322/full
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