Design of peptide-acridine mimics of ribonuclease activity.
A series of peptide-acridine conjugates was designed and synthesized, based on three features of the proposed catalytic mechanism of RNase A: 2'-proton abstraction by His-12, proton donation to the leaving 5'-oxygen by His-119, and stabilization of the pentacoordinated phosphorous transition state b...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1379732/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.15.7114 |
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