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Design of peptide-acridine mimics of ribonuclease activity.

A series of peptide-acridine conjugates was designed and synthesized, based on three features of the proposed catalytic mechanism of RNase A: 2'-proton abstraction by His-12, proton donation to the leaving 5'-oxygen by His-119, and stabilization of the pentacoordinated phosphorous transiti...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Tung, C H, Wei, Z, Leibowitz, M J, Stein, S
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 1992
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC49656/
https://ncbi.nlm.nih.gov/pubmed/1379732
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