Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling

Soluble forms of the IL-6 receptor (sIL-6R) bind to the cytokine IL-6 with similar affinity as the membrane-bound IL-6R. IL-6·sIL-6R complexes initiate IL-6 trans-signaling via activation of the ubiquitously expressed membrane-bound β-receptor glycoprotein 130 (gp130). Inhibition of IL-6 trans-signa...

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Foilsithe in:J Biol Chem
Main Authors: Wolf, Janina, Waetzig, Georg H., Chalaris, Athena, Reinheimer, Torsten M., Wege, Henning, Rose-John, Stefan, Garbers, Christoph
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965567/
https://ncbi.nlm.nih.gov/pubmed/27226573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718551
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