Caspase 3 - Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging

Mouse models of neurodegenerative diseases such as Alzheimer’s disease (AD) are important for understanding how pathological signaling cascades change neural circuitry and in time interrupt cognitive function. Here, we introduce a non-genetic preclinical model for aging and show that it exhibits cle...

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Pubblicato in:Neurochem Res
Autori principali: Means, John C., Gerdes, Bryan C., Kaja, Simon, Sumien, Nathalie, Payne, Andrew J., Stark, Danny A., Borden, Priscilla K., Price, Jeffrey L., Koulen, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965284/
https://ncbi.nlm.nih.gov/pubmed/27220334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-016-1942-9
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