Caspase 3 - Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging

Mouse models of neurodegenerative diseases such as Alzheimer’s disease (AD) are important for understanding how pathological signaling cascades change neural circuitry and in time interrupt cognitive function. Here, we introduce a non-genetic preclinical model for aging and show that it exhibits cle...

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Опубликовано в: :Neurochem Res
Главные авторы: Means, John C., Gerdes, Bryan C., Kaja, Simon, Sumien, Nathalie, Payne, Andrew J., Stark, Danny A., Borden, Priscilla K., Price, Jeffrey L., Koulen, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965284/
https://ncbi.nlm.nih.gov/pubmed/27220334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-016-1942-9
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