Caspase 3 - Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging

Mouse models of neurodegenerative diseases such as Alzheimer’s disease (AD) are important for understanding how pathological signaling cascades change neural circuitry and in time interrupt cognitive function. Here, we introduce a non-genetic preclinical model for aging and show that it exhibits cle...

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Detalhes bibliográficos
Publicado no:Neurochem Res
Main Authors: Means, John C., Gerdes, Bryan C., Kaja, Simon, Sumien, Nathalie, Payne, Andrew J., Stark, Danny A., Borden, Priscilla K., Price, Jeffrey L., Koulen, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965284/
https://ncbi.nlm.nih.gov/pubmed/27220334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-016-1942-9
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