Transgenic Rescue of the LARGE(myd) Mouse: A LARGE Therapeutic Window?

LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGE(myd) mouse results in α-DG hypoglycosylation, and is associated with central nervous system abnormalities and progressive muscular dystrophy. Up-regulation of LARGE has previously...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Hildyard, J. C. W., Lacey, E., Booler, H., Hopkinson, M., Wells, D. J., Brown, S. C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965172/
https://ncbi.nlm.nih.gov/pubmed/27467128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159853
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