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Transgenic Rescue of the LARGE(myd) Mouse: A LARGE Therapeutic Window?
LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGE(myd) mouse results in α-DG hypoglycosylation, and is associated with central nervous system abnormalities and progressive muscular dystrophy. Up-regulation of LARGE has previously...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4965172/ https://ncbi.nlm.nih.gov/pubmed/27467128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159853 |
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