Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis

BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting the joints. Anti-citrullinated protein antibodies (ACPA) are frequently found in RA. Previous studies identified a citrullinated epitope in cartilage proteoglycan (PG) aggrecan that elicited pro-inflammatory cytoki...

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Udgivet i:PLoS One
Main Authors: Markovics, Adrienn, Ocskó, Tímea, Katz, Robert S., Buzás, Edit I., Glant, Tibor T., Mikecz, Katalin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965111/
https://ncbi.nlm.nih.gov/pubmed/27466816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160284
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