Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis

Rheumatoid arthritis (RA) can be initiated and driven by immune responses to multiple antigenic epitopes including those in cartilage proteoglycan (PG, aggrecan) and type II collagen. RA is driven by T helper 1 (Th1) or Th17 pro-inflammatory T cell responses. LEAPS (Ligand Epitope Antigen Presentati...

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Bibliografische gegevens
Gepubliceerd in:Vaccines (Basel)
Hoofdauteurs: Zimmerman, Daniel H., Mikecz, Katalin, Markovics, Adrienn, Carambula, Roy E., Ciemielewski, Jason C., Toth, Daniel M., Glant, Tibor T., Rosenthal, Ken S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147650/
https://ncbi.nlm.nih.gov/pubmed/34063326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines9050448
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